CYY's Laboratory of RNA Biology &
Molecular Virology
Molecular
Virologist
For over a decade, our team has been deeply immersed in studying the fascinating interplay between host factors and positive-sense RNA viruses, with a primary focus on Orthoflaviviruses. Our research has been dedicated to dissecting the intricate mechanisms and practical implications of viral proteases as they cleave cellular substrates at the molecular level. Through our endeavors, we've nurtured a skilled team proficient in molecular biotechnology, particularly specializing in RNA and viruses. Additionally, as a mission-oriented laboratory, we've been actively engaged in RNA-related mission studies during the global response to the COVID-19 pandemic, furthering our commitment to serve society with science.
媒體報導
國家衛生研究院感染症與疫苗研究所余佳益副研究員團隊在國科會優秀年輕學者獎助計畫及國衛院院內計畫的支持下，利用順式作用的連接酶核酶(ligase ribozyme，RzL)將線性的RNA進行環化，生成環狀RNA(circRNA)，不僅具有較線狀RNA更高的穩定性，也提升了circRNA的合成效率和純度，有助未來在基因治療、疫苗開發等領域的應用。本研究成果已於2024年8月發表在國際頂尖學術期刊《Nature Communications》。
國衛院余佳益團隊研發
新式環狀RNA合成法
A cis-acting ligase ribozyme generates circular RNA in vitro for ectopic protein functioning
Chan-I Su, Zih-Shiuan Chuang, Chi-Ting Shie, Hsin-I Wang, Yu-Ting Kao & Chia-Yi Yu
Nature Communications volume 15,
Article number: 6607 (2024)
Research Interests
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RESEARCH TOPICS
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Biology of flaviviruses
-mostly dengue virus (DENV)
-Viral RNA biology and translation regulation -
RNA design
-circular RNA functioning
-RNA vaccines -
Virus-host interactions
signaling pathways:
-cGAS/STING-mediated pathways
-RIG-I/MDA5/MAVS-mediated pathways
-Inflammasome activation pathways
-ER stress and unfolded protein responses (UPR)
-Death signaling pathways
-Mitochondrial biology and mitochondrial-associated pathways
Publications
A cis-acting ligase ribozyme generates circular RNA in vitro for ectopic protein functioning.
Nature Communications volume 15, Article number: 6607 (2024)
Zika virus cleaves GSDMD to disseminate prognosticable and controllable oncolysis in a human glioblastoma cell model.
Mol Ther Oncolytics. 2023 Jan 2;28:104-117
DNA-induced 2'3'-cGAMP enhances haplotype-specific human STING cleavage by dengue protease.
Proc Natl Acad Sci U S A. 2020 Jul 7;117(27):15947-15954.
Dengue Virus Impairs Mitochondrial Fusion by Cleaving Mitofusins.
PLoS Pathogens 2015 Dec 11(12): e1005350.
Dengue virus targets the adaptor protein MITA to subvert host innate immunity.
PLoS Pathogens (2012) Jun 8(6): e1002780.