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Publications

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  1. Chan-I Su, Zih-Shiuan Chuang, Chi-Ting Shie, Hsin-I Wang, Yu-Ting Kao, Chia-Yi Yu*. A cis-acting ligase ribozyme generates circular RNA in vitro for ectopic protein functioning. 
    Nat Commun. 2024 Aug 4;15(1):6607. doi: 10.1038/s41467-024-51044-y.

  2. Yi-Sheng Kao, Li-Chiu Wang, Po-Chun Chang, Heng-Ming Lin, Yee-Shin Lin, Chia-Yi Yu, Chien-Chin Chen, Chiou-Feng Lin, Trai-Ming Yeh, Shu-Wen Wan, Jen-Ren Wang, Tzong-Shiann Ho, Chien-Chou Chu, Bo-Cheng Zhang, Chih-Peng Chang*. Negative regulation of type I interferon signaling by integrin-linked kinase permits dengue virus replication.
    PLoS Pathog. 2023 Mar 17;19(3):e1011241.

  3. Yu-Ting Kao, Hsin-I Wang, Chi-Ting Shie, Chiou-Feng Lin, Michael M.C. Lai, Chia-Yi Yu*. Zika virus cleaves GSDMD to disseminate prognosticable and controllable oncolysis in a human glioblastoma cell model. Mol Ther Oncolytics. 2023 Jan 2;28:104-117. (Corresponding author)

  4. Ting-Jing Shen, Chia-Ling Chen, Tsung-Ting Tsai, Ming-Kai Jhan, Chyi-Huey Bai, Yu-Chun Yen, Ching-Wen Tsai, Cheng-Yi Lee, Po-Chun Tseng, Chia-Yi Yu, Chiou-Feng Lin*. Hyperglycemia exacerbates dengue virus infection by facilitating poly(A)-binding protein-mediated viral translation. JCI Insight. 2022 Nov 8;7(21):e142805.

  5. Chih-Feng Tien, Wan-Ting Tsai, Chun Hwa Chen, Hui-Ju Chou, Mingzi M Zhang, Jhe-Jhih Lin, En-Ju Lin, Shih-Syong Dai, Yueh-Hsin Ping, Chia-Yi Yu, Yi-Ping Kuo, Wei-Hsiang Tsai, Hsin-Wei Chen, Guann-Yi Yu*. Glycosylation and S-palmitoylation regulate SARS-CoV-2 spike protein intracellular trafficking. iScience. 2022 Aug 19;25(8):104709.

  6. Chen-Yi Chiang, Mei-Yu Chen, Chia-Wei Hsu, Chia-Yeh Liu, Yu-Wen Tsai, Hung-Chun Liao, Jia-Ying Yan, Zih-Shiuan Chuang, Hsin-I Wang, Chien-Hsiung Pan, Chia-Yi Yu, Guann-Yi Yu, Ching-Len Liao, Shih-Jen Liu*, Hsin-Wei Chen*. Induction of high affinity monoclonal antibodies against SARS-CoV-2 variant infection using a DNA prime-protein boost strategy. J Biomed Sci. 2022 Jun 9;29(1):37.

  7. Tsai-Teng Tzeng, Kit Man Chai, Kuan-Yin Shen, Chia-Yi Yu, Shiu-Ju Yang, Wan-Chun Huang, Hung-Chun Liao, Fang-Feng Chiu, Horng-Yunn Dou, Ching-Len Liao, Hsin-Wei Chen*, Shih-Jen Liu*. A DNA vaccine candidate delivered by an electroacupuncture machine provides protective immunity against SARS-CoV-2 infection. NPJ Vaccines. 2022 Jun 3;7(1):60.

  8. Jhe-Jhih Lin, Chih-Feng Tien, Yi-Ping Kuo, En-Ju Lin, Wei-Hsiang Tsai, Ming-Yu Chen, Pei-Ju Tsai, Yu-Wen Su, Nikhil Pathak, Jinn-Moon Yang, Chia-Yi Yu, Zih-Shiuan Chuang, Han-Chieh Wu, Wan-Ting Tsai, Shih-Syong Dai, Hung-Chun Liao, Kit Man Chai, Yu-Siang Su, Tsung-Hsien Chuang, Shih-Jen Liu, Hsin-Wei Chen, Horng-Yunn Dou, Feng-Jui Chen, Chiung-Tong Chen, Chin-Len Liao, Guann-Yi Yu*. Furin and TMPRSS2 Resistant Spike Induces Robust Humoral and Cellular Immunity Against SARS-CoV-2 Lethal Infection. Front Immunol. 2022 May 2;13:872047.

  9. Wan-Ling Wu, Chen-Yi Chiang, Szu-Chia Lai, Chia-Yi Yu, Yu-Ling Huang, Hung-Chun Liao, Ching-Len Liao, Hsin-Wei Chen, Shih-Jen Liu*. Monoclonal antibody targeting the conserved region of the SARS-CoV-2 spike protein to overcome viral variants. JCI Insight. 2022 Apr 22;7(8):e157597.

  10. Ming-Kai Jhan, Chia-Ling Chen, Ting-Jing Shen, Po-Chun Tseng, Yung-Ting Wang, Rahmat Dani Satria, Chia-Yi Yu, Chiou-Feng Lin*. Polarization of Type 1 Macrophages Is Associated with the Severity of Viral Encephalitis Caused by Japanese Encephalitis Virus and Dengue Virus. Cells. 2021 Nov 15;10(11):3181.

  11. Hsin-I Wang, Zih-Shiuan Chuang, Yu-Ting Kao, Yi-Ling Lin, Jian-Jong Liang, Chun-Che Liao, Ching-Len Liao, Michael M C Lai*, Chia-Yi Yu*. Small Structural Proteins E and M Render the SARS-CoV-2 Pseudovirus More Infectious and Reveal the Phenotype of Natural Viral Variants. Int J Mol Sci. 2021 Aug 23;22(16):9087. (Co-corresponding author)

  12. Yi-Hua Pan, Mei-Ying Liao, Yu-Wen Chien, Tzong-Shiann Ho, Hui-Ying Ko, Chin-Rur Yang, Shu-Fen Chang, Chia-Yi Yu, Shu-Yu Lin, Pin-Wei Shih, Pei-Yun Shu, Day-Yu Chao, Chao-Ying Pan, Hong-Ming Chen, Guey-Chuen Perng, Chia-Chi Ku*, Chwan-Chuen King*. Use of seroprevalence to guide dengue vaccination plans for older adults in a dengue non-endemic country. PLoS Negl Trop Dis. 2021 Apr 1;15(4):e0009312.

  13. Zi-Yi Lu, Miao-Huei Cheng, Chia-Yi Yu, Yee-Shin Lin, Trai-Ming Yeh, Chia-Ling Chen, Chien-Chin Chen, Shu-Wen Wan*, Chih-Peng Chang*. Dengue Nonstructural Protein 1 Maintains Autophagy through Retarding Caspase-Mediated Cleavage of Beclin-1. Int J Mol Sci. 2020 Dec 19;21(24):9702.

  14. Chan-I Su, Yu-Ting Kao, Chao-Chen Chang, Yao Chang, Tzong-Shiann Ho, H Sunny Sun, Yi-Ling Lin, Michael M C Lai, Yu-Huei Liu, and Chia-Yi Yu*. DNA-induced 2'3'-cGAMP enhances haplotype-specific human STING cleavage by dengue protease. Proc Natl Acad Sci U S A. 2020 Jul 7;117(27):15947-15954. (Corresponding author)

  15. Yu-San Kao, Chia-Yi Yu, Hong-Jyun Huang, Sen-Mao Tien, Wan-Yu Wang, Martyr Yang, Robert Anderson, Trai-Ming Yeh, Yee-Shin Lin* and Shu-Wen Wan*. Combination of Modified NS1 and NS3 as a Novel Vaccine Strategy against Dengue Virus Infection. Journal of Immunology 2019 Oct 1; 203(7):1909-1917.

  16. Yu-Ting Kao, Michael M. C. Lai and Chia-Yi Yu*. How Dengue Virus Circumvents Innate Immunity. Frontiers in Immunology. 2018 Dec 4; 9: 2860. (Corresponding author)

  17. Yi-Lin Cheng, Yee-Shin Lin, Chia-Ling Chen, Tsung-Ting Tsai, Cheng-Chieh Tsai, Yan-Wei Wu, Yi-Dan Ou, Yu-Yi Chu, Ju-Ming Wang, Chia-Yi Yu, Chiou-Feng Lin*. Activation of Nrf2 by the dengue virus causes an increase in CLEC5A, which enhances TNF-α production by mononuclear phagocytes. Scientific Reports 2016 Aug 26;6:32000.

  18. Yan-Wei Wu, Clément Mettling, Shang-Rung Wu, Chia-Yi Yu, Guey-Chuen Perng, Yee-Shin Lin* & Yea-Lih Lin*. Autophagy-associated dengue vesicles promote viral transmission avoiding antibody neutralization. Scientific Reports 2016 Aug 25;6:32243.

  19. Chan-I Su, Chung-Hsin Tseng, Chia-Yi Yu* and Michael M. C. Lai*. SUMO Modification Stabilizes Dengue Virus Nonstructural Protein 5 to Support Virus Replication. Journal of Virology 2016 Apr 14,90(9): 4308-19. (Co-corresponding author)

  20. Chia-Yi Yu*, Jian-Jong Liang, Jin-Kun Li, Yi-Ling Lee, Bi-Lan Chang, Chan-I Su, Wei-Jheng Huang, Michael M. C. Lai and Yi-Ling Lin*. Dengue Virus Impairs Mitochondrial Fusion by Cleaving Mitofusins. PLoS Pathogens 2015 Dec 11(12): e1005350. (Co-corresponding author)

  21. Yi-Lin Cheng, Yee-Shin Lin, Chia-Ling Chen, Shu-Wen Wan, Yi-Dan Ou, Chia-Yi Yu, Tsung-Ting Tsai, Po-Chun Tseng, Chiou-Feng Lin*. Dengue virus infection causes the activation of distinct NF-kB pathways for inducible nitric oxide synthase and TNF-a expression in RAW264.7 cells. Mediators of Inflammation (2015) Jun 2015: 274025.

  22. Li-Fong Wang, You-Sheng Lin, Nan-Chieh Huang, Chia-Yi Yu, Wei-Lun Tsai, Jih-Jung Chen, Toru Kubota, Mayumi Matsuoka, Siang-Ru Chen, Chih-Shiang Yang, Ruo-Wei Lu, Yi-Ling Lin, and Tsung-Hsien Chang*. Hydroxychloroquine-Inhibited Dengue Virus Is Associated with Host Defense Machinery. J Interferon Cytokine Res. (2015) Mar 35(3):143-56

  23. Hom-Ming Yeh, Chia-Yi Yu, Ho-Chun Yang, Shih-Han Ko, Ching-Len Liao, and Yi-Ling Lin*. Ubiquitin-specific protease 13 regulates interferon signaling by stabilizing STAT1. Journal of Immunology (2013) Sep 191(6):3328-36.

  24. Yu-Chun Tu, Chia-Yi Yu, Jian-Jong Liang, Elong Lin, Ching-Len Liao, and Yi-Ling Lin*. Blocking dsRNA-Activated Protein Kinase PKR by Japanese Encephalitis Virus Nonstructural Protein 2A. Journal of Virology (2012) Oct 86(19):10347-58.

  25. Tsung-Hsien Chang*, Siang-Ru Chen, Chia-Yi Yu, You-Sheng Lin, Yao-Shen Chen, Toru Kubota, Mayumi Matsuoka and Yi-Ling Lin*. Dengue virus serotype 2 blocks extracellular signal-regulated kinase and nuclear factor-kB activation to downregulate cytokine production. PLoS One (2012) Aug 7(8): e41635.

  26. Chia-Yi Yu, Tsung-Hsien Chang, Jian-Jong Liang, Ruei-Lin Chiang, Yi-Ling Lee, Ching-Len Liao and Yi-Ling Lin*. Dengue virus targets the adaptor protein MITA to subvert host innate immunity. PLoS Pathogens (2012) Jun 8(6): e1002780. [國科會博士後研究人員學術著作獎]

  27. Jian-Jong Liang, Chia-Yi Yu, Ching-Len Liao, and Yi-Ling Lin*. Vimentin binding is critical for infection by the virulent strain of Japanese encephalitis virus. Cellular Microbiology (2011) Sep 13(9):1358-70.

  28. Chia-Yi Yu, Ruei-Lin Chiang, Tsung-Hsien Chang, Ching-Len Liao, and Yi-Ling Lin*. The interferon stimulator mitochondrial antiviral signaling protein facilitates cell death by disrupting the mitochondrial membrane potential and by activating caspases. Journal of Virology (2010) Mar 84(5):2421-31.

  29. Chia-Yi Yu, Yun-Wei Hsu, Ching-Len Liao, and Yi-Ling Lin*. Flavivirus infection activates the XBP1 pathway of the unfolded protein response to cope with endoplasmic reticulum stress. Journal of Virology (2006) Dec 80(23):11868-80.

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